{"id":16511,"date":"2023-09-13T09:58:26","date_gmt":"2023-09-13T09:58:26","guid":{"rendered":"https:\/\/makingpharmaindustry.it\/non-categorizzato\/new-drug-candidates-to-fight-sepsis\/"},"modified":"2023-09-13T10:26:33","modified_gmt":"2023-09-13T10:26:33","slug":"new-drug-candidates-to-fight-sepsis","status":"publish","type":"post","link":"https:\/\/makingpharmaindustry.it\/en\/events\/new-drug-candidates-to-fight-sepsis\/","title":{"rendered":"New drug candidates to fight sepsis"},"content":{"rendered":"<p><span class=\"ng-star-inserted\" data-index=\"0\"><a href=\"https:\/\/www.worldsepsisday.org\/wsd2023\" target=\"_blank\" rel=\"noopener\">World Sepsis Day<\/a> is celebrated on 13 September, a global initiative to raise public awareness of sepsis, to improve its prevention, recognition and clinical management.<\/span><\/p>\n<p><span class=\"ng-star-inserted\" data-index=\"1\">By sepsi we mean &#8211; as defined in 2016 by the European Society of Intensive Care Medicine and the Society of Critical Care Medicine &#8211; <strong>a life-threatening organ dysfunction caused by an inappropriate host response to an infection<\/strong> and represents a <strong>global emergency<\/strong>.<\/span><\/p>\n<p><span class=\"ng-star-inserted\" data-index=\"2\">Worldwide, about <strong>50 million cases<\/strong> of sepsis occur every year, of which only 20% occur in hospital.<br \/>\n<\/span><span class=\"ng-star-inserted\" data-index=\"3\">Globally, <strong>1 in 5 deaths is associated with sepsis<\/strong>, for a total of at least 11 million deaths a year, equal to one death every 2.8 seconds. <\/span><span class=\"ng-star-inserted\" data-index=\"4\">Survivors often experience permanent disabilities.<\/span><\/p>\n<p><span class=\"ng-star-inserted\" data-index=\"5\"><strong>40% of cases of sepsis refer to children<\/strong> under 5 years of age. <\/span><span class=\"ng-star-inserted hovered\" data-index=\"6\">In industrialized countries it can cause death in 3-4% of newborns and up to 24% of newborns born in developing countries. <\/span><span class=\"ng-star-inserted\" data-index=\"7\">Around 680,000 neonatal deaths from sepsis occur worldwide each year, with a particularly high risk in India, Pakistan, Nigeria, Congo, and China.<br \/>\n<\/span><span class=\"ng-star-inserted\" data-index=\"8\">Neonatal sepsis can also lead to serious clinical manifestations, often associated with long-term irreversible deficits.<\/span><\/p>\n<h2>The importance of prevention<\/h2>\n<p><span class=\"ng-star-inserted\" data-index=\"4\">Specific azons exist to improve the prevention of infections and to combat the fight against sepsis. <\/span><span class=\"ng-star-inserted hovered\" data-index=\"5\">International organizations, such as <\/span><em><a href=\"https:\/\/www.who.int\/about\/governance\/world-health-assembly\">World Health Assembly<\/a>\u00a0(<\/em>WHA),\u00a0<a href=\"https:\/\/www.esicm.org\/\"><em>The European Society of Intensive Care Medicine<\/em><\/a>\u00a0(ESICM),\u00a0<a href=\"https:\/\/www.global-sepsis-alliance.org\/\"><em>The Global Sepsis Alliance<\/em><\/a>\u00a0(GSA) e\u00a0<em><a href=\"https:\/\/www.sccm.org\/Home\">The Society of Critical Care Medicine<\/a><\/em> (SCCM), suggest:<\/p>\n<ul>\n<li><span class=\"ng-star-inserted hovered\" data-index=\"6\">frequent hand hygiene performed correctly<\/span><\/li>\n<li><span class=\"ng-star-inserted\" data-index=\"7\">scrupulous application of infection prevention and control (IPC) measures in treatment settings<\/span><\/li>\n<li><span class=\"ng-star-inserted\" data-index=\"8\">regular updating of healthcare personnel on IPC and antimicrobial-resistant infections<\/span><\/li>\n<li><span class=\"ng-star-inserted\" data-index=\"9\">availability of safe and clean environments for childbirth<\/span><\/li>\n<li><span class=\"ng-star-inserted\" data-index=\"10\">use of available vaccinations.<\/span><\/li>\n<\/ul>\n<p>Anaelle Tannen, Infectious Disease Analyst di <a href=\"https:\/\/www.globaldata.com\/\">GlobalData<\/a>, comments: &#8220;Sepsis is a somewhat preventable illness, and more is needed to educate individuals on the disease and the methods of prevention. Timely intervention is crucial, but the limited awareness surrounding the condition represents a barrier to the early recognition and treatment and therefore contributes to the high mortality rate&#8221;.<\/p>\n<h2>New possible treatments in development<\/h2>\n<p>Today, for the treatment of sepsis, <strong>generic antibiotics<\/strong> are usually used along with supportive therapies.<\/p>\n<p>However, according to GlobalData, the lack of drugs specifically used to treat the pathophysiology of sepsis is another urgent unmet need in this area.<br \/>\nTannen adds: \u201cOnly two drugs, La Jolla\u2019s Giapreza (angiotensin II acetate) in 2017, and Shionogi\u2019s Fetroja (cefiderocol) in 2019, have been approved for sepsis in the last 20 years. There have also been a number of high-profile failures in the sepsis market over the recent years, with drugs such as Eisai\u2019s eritoran tetrasodium, AstraZeneca and BTG\u2019s Cytofab (AZD-9773), and AstraZeneca and BTG\u2019s Cytofab failing to meet their primary endpoints in clinical trials.\u201d<\/p>\n<p>According to GlobalData, <strong>there are currently 168 drugs in the pipeline, 25 of which are in late-stage development<\/strong> (Phase II, Phase III, or Pre-registration stage). These include Adrenomed AG\u2019s adrecizumab (a monoclonal antibody targeting adrenomedullin), Inotrems SA\u2019s Motrem (a Triggering Receptor Expressed On Monocytes (TREM)-1 inhibitor), and RevImmune SAS\u2019s CYT107 (an Interleukin (IL)-7 agonist), all of which are in Phase II development.<br \/>\nGlobalData forecasts the collective revenue for adrecizumab, motrem and CYT107 to reach $2.2 billion in 2030.<br \/>\nTannen concludes: \u201cWith an expansive number of drugs in the pipeline, there is potential for sepsis to become more treatable in the near future. If approved, candidates such as adrecizumab, Motrem, and CYT107 are expected to supplement existing antibiotic treatments\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>September 13 is World Sepsis Day. According to GlobalData there are several new drug candidates in advanced stage of study: a hope to make the pathology more easily treatable <\/p>\n","protected":false},"author":32,"featured_media":16514,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[804],"tags":[],"class_list":{"0":"post-16511","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-events"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>New drug candidates to fight sepsis - MakingPharmaIndustry<\/title>\n<meta name=\"description\" content=\"September 13 is the World Sepsis Day: new drug candidates in advanced stage of study to make treatment easier\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/makingpharmaindustry.it\/en\/events\/new-drug-candidates-to-fight-sepsis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New drug candidates to fight sepsis - 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